Abstract: The article is a collaborative writing venture drawing on research findings from New Zealand and Iceland to contribute to the international scholarship on the status and future direction of the nursing discipline. It takes an overview of the international historical trends in nursing knowledge development and proposes a framework for contemporary nursing research that accommodates the past efforts and paradigms of nurse scholars and reflects the changing thinking around the humanness of the health circumstance as the focus of the nursing discipline. It addresses contemporary challenges facing nurses as practitioners and researchers for advancement of practice and delivery of health services, and for influencing health policy.