Abstract: This systematic review was conducted by the New Zealand Centre for Evidence Based Nursing, a collaborating centre of The Joanna Briggs Institute for Evidence Based Nursing and Midwifery. The aim was to present the best available evidence on interventions, which are effective in preventing or reducing the prevalence of complications associated with suctioning, in hospitalised adult patients with an artificial airway who are breathing spontaneously or are artificially ventilated and who require suctioning. The specific questions addressed were as follows: Which methods of suctioning reduce the prevalence of mucosal trauma or mucosal dysfunction, and promote the removal of respiratory secretions? Which techniques or methods are effective in reducing the occurrence of suctioning -induced hypoxaemia, during or following the suctioning procedure? Which techniques or methods are effective in minimising the haemodynamic or pulmonary complications associated with the suctioning procedure?